To B or not to B: PIP2 answers the question.
نویسندگان
چکیده
In a recent issue of Molecular Cell, Papayannopoulos et al. (2005) show that N-WASP activation of actin-related protein2/3 (Arp2/3) is ultrasensitive to PI(4,5)P(2) concentration. We discuss how interactions between basic regions in proteins and negatively charged membranes can produce sharp on-off switches that may regulate biological activity.
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عنوان ژورنال:
- Developmental cell
دوره 8 2 شماره
صفحات -
تاریخ انتشار 2005